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1

Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies

John Wijdenes, Peter C. Heinrich, Gerhard Müller-Newen, Catherine Roche, Zong-Jiang Gu, Claude Clément, Bernard Klein

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 814 KB

english, 1995

2

Development of an IL-6 Inhibitor Based on the Functional Analysis of Murine IL-6Rα1

Monique Y. Wiesinger, Serge Haan, Stefan Wüller, Maria-Elisabeth Kauffmann, Tobias Recker, Andrea Küster, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 1.57 MB

english, 2009

3

A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor

Andreas Timmermann, Andrea Küster, Ingo Kurth, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

2002

Language:

english

File:

PDF, 386 KB

english, 2002

4

A receptor fusion protein for the inhibition of murine oncostatin M

Liv Brolund, Andrea Küster, Sabrina Korr, Michael Vogt, Gerhard Müller-Newen

Journal:

BMC Biotechnology

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

5

Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer

Nicole Deutscher, Frauke Bataille, Martin Hausmann, Stephan Kiessling, Gerhard Muller-Newen, Sandra N. Leeb, Hans Herfarth, Peter C. Heinrich, Jürgen Schölmerich, Gerhard Rogler

Journal:

International Journal of Colorectal Disease

Year:

2006

Language:

english

File:

PDF, 568 KB

english, 2006

6

Bow to your partner for signaling

Müller-Newen, Gerhard, Heinrich, Peter C, Haan, Serge, Hermanns, Heike M

Journal:

Nature Structural and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 437 KB

english, 2005

7

The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region

Thomas Kernebeck, Stefan Pflanz, Peter C. Heinrich, Axel Wollmer, Joachim Grötzinger, Gerhard Müller-Newen, Günther Kurapkat, Stephan Grzesiek, Ruud M. Scheek, Klaas Dijkstra

Journal:

Protein Science

Year:

1999

Language:

english

File:

PDF, 2.19 MB

english, 1999

8

Dynamics and non-canonical aspects of JAK/STAT signalling

Anne Mohr, Nicolas Chatain, Tamás Domoszlai, Natalie Rinis, Michael Sommerauer, Michael Vogt, Gerhard Müller-Newen

Journal:

European Journal of Cell Biology

Year:

2012

Language:

english

File:

PDF, 1.43 MB

english, 2012

9

Receptor fusion proteins for the inhibition of cytokines

Dieter Schwache, Gerhard Müller-Newen

Journal:

European Journal of Cell Biology

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

10

Cytokines and inflammation

Jürgen Floege, Bernhard Lüscher, Gerhard Müller-Newen

Journal:

European Journal of Cell Biology

Year:

2012

Language:

english

File:

PDF, 89 KB

english, 2012

11

Monoclonal antibodies against the human interleukin-11 receptor alpha-chain (IL-11Rα) and their use in studies of human mononuclear cells

Chrystel Blanc, Patricia Vusio, Karin Schleinkofer, Olivier Boisteau, Stefan Pflanz, Stéphane Minvielle, Joachim Grötzinger, Gerhard Müller-Newen, Peter C Heinrich, Yannick Jacques, Félix A Montero-Ju

Journal:

Journal of Immunological Methods

Year:

2000

Language:

english

File:

PDF, 1.37 MB

english, 2000

12

Enoyl-CoA Hydratase and Isomerase form a Superfamily with a Common Active-Site Glutamate Residue

Gerhard Müller-Newen, Uwe Janssen, Wilhelm Stoffel

Journal:

Year:

1995

Language:

english

File:

PDF, 723 KB

english, 1995

13

Soluble Human Interleukin-6 Receptor : Expression in Insect Cells, Purification and Characterization

Oliver Weiergräber, Ulrike Hemmann, Andrea Küster, Gerhard Müller-Newen, Johannes Schneider, Stefan Rose-John, Peter Kurschat, Just P. J. Brakenhoff, Margreet H. L. Hart, Silvia Stabel, Peter C. Heinr

Journal:

Year:

1995

Language:

english

File:

PDF, 970 KB

english, 1995

14

Purification and Characterization of the Soluble Interleukin-6 Receptor from Human Plasma and Identification of An Isoform Generated through Alternative Splicing

Gerhard Müller-newen, Christian Köhne, Radovan Keul, Ulrike Hemmann, Werner Müller-esterl, John Wijdenes, Just P. J. Brakenhoff, Margreet H. L. Hart, Peter C. Heinrich

Journal:

Year:

1996

Language:

english

File:

PDF, 803 KB

english, 1996

15

The Signal Transducer Gp130 — Bacterial Expression, Refolding and Properties of the Carboxy-Terminal Domain of the Cytokine-Binding Module

Gerhard Müller-Newen, Stefan Pflanz, Ulrich Hassiepen, Jürgen Stahl, Axel Wollmer, Peter C. Heinrich, Joachim Grötzinger

Journal:

Year:

1997

Language:

english

File:

PDF, 716 KB

english, 1997

16

Real time analysis of oncogenic STAT3 in single cells

Andreas Herrmann, Michael Vogt, Martin Mönnigmann, Ulrike Sommer, Serge Haan, Valeria Poli, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Biomedicine & Pharmacotherapy

Year:

2006

Language:

english

File:

PDF, 181 KB

english, 2006

17

JAK/STAT signaling in cancer

Peter C. Heinrich, Serge Haan, Kevin W. Harris, Heike M. Hermanns, Silke Metz, Gerhard Müller-Newen, Fred Schaper, Monique Wiesinger

Journal:

Biomedicine & Pharmacotherapy

Year:

2006

Language:

english

File:

PDF, 142 KB

english, 2006

18

Characterization of gene-targeted murine embryonic stem cells expressing a STAT3-YFP allele

Anne Schmitt, Andrea Küster, Rebekka Schneider, Martin Zenke, Valeria Poli, Gerhard Müller-Newen

Journal:

Year:

2009

Language:

english

File:

PDF, 60 KB

english, 2009

19

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3

Michael Vogt, Tamas Domoszlai, Dzina Kleshchanok, Swen Lehmann, Walter Richtering, Gerhard Müller-Newen

Journal:

Year:

2009

Language:

english

File:

PDF, 44 KB

english, 2009

20

Directed immobilization of fluorescently labelled cytokines for the analysis of their signal transduction by confocal microscopy

Tobias Recker, Daniel Haamann, Doris Klee, Stefan Barth, Gerhard Müller-Newen

Journal:

Year:

2009

Language:

english

File:

PDF, 44 KB

english, 2009

21

Differential tyrosine phosphorylation of the STAT5A transcription factor by oncogenic kinases

Nicolas Chatain, Michael Vogt, Stefan N. Constantinescu, Marc Kerenyi, Matthias Mayerhofer, Richard Moriggl, Veronika Sexl, Gerhard Müller-Newen

Journal:

Year:

2009

Language:

english

File:

PDF, 44 KB

english, 2009

22

Plasticity and cross-talk of Interleukin 6-type cytokines

Christoph Garbers, Heike M. Hermanns, Fred Schaper, Gerhard Müller-Newen, Joachim Grötzinger, Stefan Rose-John, Jürgen Scheller

Journal:

Cytokine & Growth Factor Reviews

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

23

Different epitopes are required for gp130 activation by interleukin-6, oncostatin M and leukemia inhibitory factor

Andreas Timmermann, Stefan Pflanz, Joachim Grötzinger, Andrea Küster, Ingo Kurth, Vincent Pitard, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

2000

Language:

english

File:

PDF, 396 KB

english, 2000

24

Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties

Benoı̂t Lebeau, Felix A Montero Julian, John Wijdenes, Gerhard Müller-Newen, Heike Dahmen, Michel Chérel, Peter C Heinrich, Hervé Brailly, Marie-Martine Hallet, Anne Godard, Stéphane Minvielle, Yannic

Journal:

Year:

1997

Language:

english

File:

PDF, 735 KB

english, 1997

25

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130

Stefan Thiel, Heike Dahmen, Astrid Martens, Gerhard Müller-Newen, Fred Schaper, Peter C. Heinrich, Lutz Graeve

Journal:

Year:

1998

Language:

english

File:

PDF, 122 KB

english, 1998

26

A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130

Stefan Pflanz, Ingrid Tacken, Joachim Grötzinger, Yannick Jacques, Heike Dahmen, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

1999

Language:

english

File:

PDF, 338 KB

english, 1999

27

Erratum to: A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130 (FEBS 21942): [FEBS Letters 450 (1999) 117–122]

Stefan Pflanz, Ingrid Tacken, Joachim Grötzinger, Yannick Jacques, Stéphane Minvielle, Heike Dahmen, Peter C. Heinrich, Gerhard Müller-Newen

Journal:

Year:

1999

Language:

english

File:

PDF, 24 KB

english, 1999

28

Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation

Seré, Kristin, Baek, Jea-Hyun, Ober-Blöbaum, Julia, Müller-Newen, Gerhard, Tacke, Frank, Yokota, Yoshifumi, Zenke, Martin, Hieronymus, Thomas

Journal:

Year:

2012

Language:

english

File:

PDF, 1.96 MB

english, 2012

29

Identification of the domain in the human interleukin-11 receptor that mediates ligand binding

Karin Schleinkofer, Andrew Dingley, Ingrid Tacken, Matthias Federwisch, Gerhard Müller-Newen, Peter C Heinrich, Patricia Vusio, Yannick Jacques, Joachim Grötzinger

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 338 KB

english, 2001

30

Cellular uptake of fluorophore-labeled glyco-DNA–gold nanoparticles

Witten, Katrin G., Ruff, Julie, Mohr, Anne, Görtz, Dieter, Recker, Tobias, Rinis, Natalie, Rech, Claudia, Elling, Lothar, Müller-Newen, Gerhard, Simon, Ulrich

Journal:

Journal of Nanoparticle Research

Year:

2013

Language:

english

File:

PDF, 669 KB

english, 2013

31

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, Peter C., BEHRMANN, Iris, HAAN, Serge, HERMANNS, Heike M., MÜLLER-NEWEN, Gerhard, SCHAPER, Fred

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 466 KB

english, 2003

32

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3

Ginter, Torsten, Fahrer, Jörg, Kröhnert, Ulrike, Fetz, Verena, Garrone, Alessio, Stauber, Roland H., Reichardt, Werner, Müller-Newen, Gerhard, Kosan, Christian, Heinzel, Thorsten, Krämer, Oliver H.

Journal:

Cellular Signalling

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

33

159

Rinis, Natalia, Müller-Newen, Gerhard

Journal:

Year:

2014

Language:

english

File:

PDF, 56 KB

english, 2014

34

Latent MMP-9 is bound to TIMP-1 before secretion

Roderfeld, Martin, Graf, Jürgen, Giese, Bernd, Salguero-Palacios, Rebeca, Tschuschner, Annette, Müller-Newen, Gerhard, Roeb, Elke

Journal:

Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 372 KB

english, 2007

35

Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies

Rinis, Natalie, Küster, Andrea, Schmitz-Van de Leur, Hildegard, Mohr, Anne, Müller-Newen, Gerhard

Journal:

Cell Communication and Signaling

Year:

2014

Language:

english

File:

PDF, 1.68 MB

english, 2014

36

Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction

Fahrenkamp, Dirk, de Leur, Hildegard, Küster, Andrea, Chatain, Nicolas, Müller-Newen, Gerhard

Journal:

Cell Communication and Signaling

Year:

2015

Language:

english

File:

PDF, 2.54 MB

english, 2015

37

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

Schneider, Rebekka K, Ziegler, Susanne, Leisten, Isabelle, Ferreira, Monica, Schumacher, Anne, Rath, Björn, Fahrenkamp, Dirk, Müller-Newen, Gerhard, Crysandt, Martina, Wilop, Stefan, Jost, Edgar, Kosc

Journal:

Journal of Hematology & Oncology

Year:

2014

Language:

english

File:

PDF, 1.43 MB

english, 2014

38

Mitochondrial 3-2 trans -Enoyl-CoA Isomerase. Purification, Cloning, Expression, and Mitochondrial Import of the Key Enzyme of Unsaturated Fatty acid β -Oxidation

MÜLLER-NEWEN, Gerhard, STOFFEL, Wilhelm

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1991

Language:

english

File:

PDF, 1.80 MB

english, 1991

39

Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity

Papadopoulos, Chrisovalantis, Arato, Krisztina, Lilienthal, Eva, Zerweck, Johannes, Schutkowski, Mike, Chatain, Nicolas, Müller-Newen, Gerhard, Becker, Walter, de la Luna, Susana

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 3.54 MB

english, 2011

40

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

HEINRICH, Peter C., BEHRMANN, Iris, MÜLLER-NEWEN, Gerhard, SCHAPER, Fred, GRAEVE, Lutz

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 676 KB

english, 1998

41

Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3 nuclear trafficking

Martincuks, Antons, Fahrenkamp, Dirk, Haan, Serge, Herrmann, Andreas, Küster, Andrea, Müller-Newen, Gerhard

Journal:

Cellular Signalling

Year:

2016

Language:

english

File:

PDF, 2.49 MB

english, 2016

42

Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes

Martin, Lukas, Peters, Carsten, Schmitz, Susanne, Moellmann, Julia, Martincuks, Antons, Heussen, Nicole, Lehrke, Michael, Müller-Newen, Gerhard, Marx, Gernot, Schuerholz, Tobias

Journal:

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

43

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

FISCHER, Patrick, LEHMANN, Ute, SOBOTA, Radoslaw M., SCHMITZ, Jochen, NIEMAND, Claudia, LINNEMANN, Sonja, HAAN, Serge, BEHRMANN, Iris, YOSHIMURA, Akihiko, JOHNSTON, James A., MÜLLER-NEWEN, Gerhard, HE

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 472 KB

english, 2004

44

Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor

THIEL, Stefan, BEHRMANN, Iris, TIMMERMANN, Andreas, DAHMEN, Heike, MÜLLER-NEWEN, Gerhard, SCHAPER, Fred, TAVERNIER, Jan, PITARD, Vincent, HEINRICH, Peter C., GRAEVE, Lutz

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 215 KB

english, 1999

45

Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential

PFLANZ, Stefan, KERNEBECK, Thomas, GIESE, Bernd, HERRMANN, Andreas, PACHTA-NICK, Michael, STAHL, Jürgen, WOLLMER, Axel, HEINRICH, Peter C., MÜLLER-NEWEN, Gerhard, GRÖTZINGER, Joachim

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 225 KB

english, 2001

46

Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions

DAHMEN, Heike, HORSTEN, Ursula, KÜSTER, Andrea, JACQUES, Yannick, MINVIELLE, Stéphane, KERR, Ian M., CILIBERTO, Gennaro, PAONESSA, Giacomo, HEINRICH, Peter C., MÜLLER-NEWEN, Gerhard

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 424 KB

english, 1998

47

Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor

THIEL, Stefan, BEHRMANN, Iris, TIMMERMANN, Andreas, DAHMEN, Heike, MÜLLER-NEWEN, Gerhard, SCHAPER, Fred, TAVERNIER, Jan, PITARD, Vincent, HEINRICH, Peter C., GRAEVE, Lutz

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 215 KB

english, 1999

48

Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential

PFLANZ, Stefan, KERNEBECK, Thomas, GIESE, Bernd, HERRMANN, Andreas, PACHTA-NICK, Michael, STAHL, Jürgen, WOLLMER, Axel, HEINRICH, Peter C., MÜLLER-NEWEN, Gerhard, GRÖTZINGER, Joachim

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 225 KB

english, 2001

49

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

Fahrenkamp, Dirk, Li, Jinyu, Ernst, Sabrina, Schmitz-Van de Leur, Hildegard, Chatain, Nicolas, Küster, Andrea, Koschmieder, Steffen, Lüscher, Bernhard, Rossetti, Giulia, Müller-Newen, Gerhard

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.56 MB

english, 2016

50

Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling

Broda, Janine, Küster, Andrea, Westhues, Stefan, Fahrenkamp, Dirk, Vogg, Andreas T. J., Steitz, Julia, Mottaghy, Felix M., Müller-Newen, Gerhard, Simon, Ulrich

Journal:

Advanced Healthcare Materials

Year:

2016

Language:

english

File:

PDF, 2.01 MB

english, 2016

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